an epidemiological study of concomitant use of chinese medicine and antipsychotics in schizophrenic patients implication for herb-drug interaction流行病学的研究同时使用中医和精神分裂症患者的抗精神病药物为herb-drug交互影响.pdfVIP
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an epidemiological study of concomitant use of chinese medicine and antipsychotics in schizophrenic patients implication for herb-drug interaction流行病学的研究同时使用中医和精神分裂症患者的抗精神病药物为herb-drug交互影响
An Epidemiological Study of Concomitant Use of Chinese
Medicine and Antipsychotics in Schizophrenic Patients:
Implication for Herb-Drug Interaction
1,2 2 1 3 2 4
Zhang-Jin Zhang *, Qing-Rong Tan *, Yao Tong , Xue-Yi Wang , Huai-Hai Wang , Lai-Ming Ho , Hei Kiu
1 1 1 5 6 7
Wong , Yi-Bin Feng , Di Wang , Roger Ng , Grainne M. McAlonan , Chuan-Yue Wang , Vivian Taam
Wong8
1 School of Chinese Medicine, Faculty of Medicine, the University of Hong Kong, Hong Kong, China, 2 Department of Psychiatry, Fourth Military Medical University, Xijing
Hospital, Xi’an, Shaanxi, China, 3 Mental Health Center, Hebei Medical University, Shijiazhuang, Hebei, China, 4 School of Public Health, the University of Hong Kong, Hong
Kong, China, 5 Department of Psychiatry, Kowloon Hospital, Hong Kong, China, 6 Department of Psychiatry, the University of Hong Kong, Hong Kong, China, 7 Capital
Medical University, Beijing Anding Hospital, Beijing, China, 8 Chinese Medicine Section, Hospital Authority, Hong Kong, China
Abstract
Background: Herb-drug interactions are an important issue in drug safety and clinical practice. The aim of this
epidemiological study was to characterize associations of clinical outcomes with concomitant herbal and antipsychotic use
in patients with schizophrenia.
Methods and Findings: In this retrospective, cross-sectional study, 1795 patients with schizophrenia who were randomly
selected from 17 psychiatric hospitals in China were interviewed face-to-face using a structured questionnaire. Association
analyses were conducted to examine correlates between Chinese medicine (CM) use and demographic, clinical var
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