an ep-icd based index is a marker of aggressiveness and poor prognosis in thyroid carcinoma基于ep-icd指数是一个侵略性的标志和甲状腺癌预后不良.pdfVIP

An Ep-ICD Based Index Is a Marker of Aggressiveness and Poor Prognosis in Thyroid Carcinoma 1 1 1 1 3,4 3,4 Helen C.-H. He , Lawrence Kashat , Ipshita Kak , Tada Kunavisarut , Raefe Gundelach , Dae Kim , 1 5 3,4 1,2,3,5,6 . Anthony K.-C. So , Christina MacMillan , Jeremy L. Freeman , Ranju Ralhan * , 1,2,3,4,5,6 . Paul G. Walfish * 1 Alex and Simona Shnaider Laboratory in Molecular Oncology, Department of Pathology Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada, 2 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, 3 Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Department of Otolaryngology-Head and Neck Surgery Program, Mount Sinai Hospital, Toronto, Ontario, Canada, 4 Department of Medicine, Endocrine Division of Mount Sinai Hospital and University of Toronto Medical School, Toronto, Ontario, Canada, 5 Department of Pathology Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada, 6 Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada Abstract Background: Nuclear accumulation of the intracellular domain of epithelial cell adhesion molecule (Ep-ICD) in tumor cells was demonstrated to predict poor prognosis in thyroid carcinoma patients in our earlier study. Here, we investigated the clinical significance of Ep-ICD subcellular localization index (ESLI) in distinguishing aggressive papillary thyroid carcinoma (PTC) from non-aggressive cases. Meth