有哪些信誉好的足球投注网站amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer放大20问染色体臂的转换发生在肿瘤发生的早期,可能引发癌症.pdfVIP
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amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer放大20问染色体臂的转换发生在肿瘤发生的早期,可能引发癌症
Amplification of the 20q Chromosomal Arm Occurs Early
in Tumorigenic Transformation and May Initiate Cancer
1,2.¤ 2. 2 2 2
Yuval Tabach , Ira Kogan-Sakin , Yosef Buganim , Hilla Solomon , Naomi Goldfinger , Randi
3,4 5,6 5,6 5,6 2 1
Hovland , Xi-Song Ke , Anne M. Oyan , Karl-H. Kalland , Varda Rotter , Eytan Domany *
1 Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel, 2 Department of Molecular Cell Biology, Weizmann Institute of Science,
Rehovot, Israel, 3 Department of Medicine, Haukeland University Hospital, Bergen, Norway, 4 Department of Biomedicine, University of Bergen, Bergen, Norway, 5 The
Gade Institute, University of Bergen, Bergen, Norway, 6 Department of Microbiology, Haukeland University Hospital, Bergen, Norway
Abstract
Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast
cancer, suggesting that 20q amplification may play a causal role in tumorigenesis. According to an alternative view,
chromosomal imbalance is mainly a common side effect of cancer progression. To test whether a specific genomic
aberration might serve as a cancer initiating event, we established an in vitro system that models the evolutionary process
of early stages of prostate tumor formation; normal prostate cells were immortalized by the over-expression of human
telomerase catalytic subunit hTERT, and cultured for 650 days till several transformation hallmarks were observed. Gene
expression patterns were measured
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