有哪些信誉好的足球投注网站age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat与年龄有关的破坏分子钟表达在自发性高血压大鼠的骨骼肌.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Age-Associated Disruption of Molecular Clock Expression
in Skeletal Muscle of the Spontaneously Hypertensive
Rat
1. 1 . 1 2
Mitsunori Miyazaki , Elizabeth Schroder * , Stephanie E. Edelmann , Michael E. Hughes , Karl
3 4 1
Kornacker , C. William Balke , Karyn A. Esser
1 Department of Physiology, Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States of America, 2 Department of Cellular and Molecular
Physiology, Yale School of Medicine, New Haven, Connecticut, United States of America, 3 Division of Sensory Biophysics, Ohio State University, Columbus, Ohio, United
States of America, 4 Clinical and Translational Science Institute and the Department of Medicine, University of California San Francisco, San Francisco, California, United
States of America
Abstract
It is well known that spontaneously hypertensive rats (SHR) develop muscle pathologies with hypertension and heart failure,
though the mechanism remains poorly understood. Woon et al. (2007) linked the circadian clock gene Bmal1 to
hypertension and metabolic dysfunction in the SHR. Building on these findings, we compared the expression pattern of
several core-clock genes in the gastrocnemius muscle of aged SHR (80 weeks; overt heart failure) compared to aged-
matched control WKY strain. Heart failure was associated with marked effects on the expression of Bmal1, Clock and Rora in
addition to several non-circadian genes important in regulating skeletal muscle phenotype including Mck, Ttn and Mef2c.
We next performed circadian time-course collections at a young age (8 weeks; pre-hypertensive) and adult age (22 weeks;
hypertensive) to
您可能关注的文档
- acral lentiginous melanoma in situ a diagnostic and management challenge肢端的雀斑的原位黑色素瘤诊断和管理的挑战.pdf
- acsl6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposureacsl6与烟熏的数量及其表达式被慢性尼古丁暴露.pdf
- acinetobacter baumannii infection inhibits airway eosinophilia and lung pathology in a mouse model of allergic asthma鲍曼不动杆菌感染抑制气道嗜酸性粒细胞和肺部病理学在过敏性哮喘小鼠模型.pdf
- acrb trimer stability and efflux activity, insight from mutagenesis studiesacrb三聚物的稳定性和流出活动,洞察力从诱变研究.pdf
- acquired type iii secretion system determines environmental fitness of epidemic vibrio parahaemolyticus in the interaction with bacterivorous protists获得iii型分泌系统确定环境的健身流行弧菌parahaemolyticus bacterivorous原生生物的相互作用.pdf
- acquisition of human-type receptor binding specificity by new h5n1 influenza virus sublineages during their emergence in birds in egypt收购生活由新的h5n1型流感病毒受体结合特异性sublineages在鸟类出现在埃及.pdf
- actin—towards a deeper understanding of the relationship between tissue context, cellular function and tumorigenesisactin-towards更深入地理解之间关系的组织背景下,细胞功能和肿瘤发生.pdf
- across bacterial phyla, distantly-related genomes with similar genomic gc content have similar patterns of amino acid usage在细菌类群,较为疏远的基因组具有相似基因的氨基酸使用gc含量也有类似的模式.pdf
- actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletion肌动蛋白和dynamin-dependent成熟突触后的体积内吞作用恢复神经传递损耗.pdf
- actinopyga lecanora hydrolysates as natural antibacterial agentsactinopyga lecanora玉米胚芽蛋白酶解物自然抗菌药物.pdf
- age of the association between helicobacter pylori and man幽门螺杆菌和人类之间的关系的时代.pdf
- age-dependent ocular dominance plasticity in adult mice年龄相关性在成年老鼠眼优势可塑性.pdf
- age-dependent maturation of toll-like receptor-mediated cytokine responses in gambian infants年龄相关性成熟toll样受体介导的细胞因子反应在冈比亚的婴儿.pdf
- age-dependent terminal declines in reproductive output in a wild bird年龄相关性终端下降在野生鸟类繁殖输出.pdf
- age-related attenuation of dominant hand superiority与年龄相关的衰减优势手的优势.pdf
- age-dependent changes in the proteome following complete spinal cord transection in a postnatal south american opossum (monodelphis domestica)年龄相关性变化的蛋白质组完成脊髓横断后产后南美负鼠(把).pdf
- ageing increases vulnerability to aβ42 toxicity in drosophila老龄化增加漏洞在果蝇aβ42毒性.pdf
- age-dependent tlr3 expression of the intestinal epithelium contributes to rotavirus susceptibility肠上皮细胞的年龄相关性tlr3表达对轮状病毒的易感性.pdf
- age-dependent targeting of protein phosphatase 1 to ca2+calmodulin-dependent protein kinase ii by spinophilin in mouse striatum年龄相关性目标蛋白质磷酸酶1 ca2 + calmodulin-dependent spinophilin蛋白激酶二世的鼠纹状体.pdf
- age-related changes in task related functional network connectivity与年龄相关的变化任务相关的功能网络连接.pdf
文档评论（0）