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ampk α1 activation is required for stimulation of glucose uptake by twitch contraction, but not by h2o2, in mouse skeletal muscle需要激活ampkα1刺激葡萄糖摄取的抽动收缩,但不是由过氧化氢,在小鼠骨骼肌
AMPK a1 Activation Is Required for Stimulation of
Glucose Uptake by Twitch Contraction, but Not by H O ,
2 2
in Mouse Skeletal Muscle
1 2,3 4,5 1 1
Thomas E. Jensen , Peter Schjerling , Benoit Viollet , Jørgen F. P. Wojtaszewski , Erik A. Richter *
1 Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of
Copenhagen, Copenhagen, Denmark, 2 Copenhagen Muscle Research Centre, Department of Molecular Muscle Biology, Rigshospitalet, Copenhagen, Denmark, 3 Medical
´
Muscle Research Cluster, Molecular Muscle Biology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, 4 Institut Cochin, Universite
Paris Descartes, CNRS (UMR 8104), Paris, France, 5 Inserm, U567, Paris, France
Abstract
Background: AMPK is a promising pharmacological target in relation to metabolic disorders partly due to its non-insulin
dependent glucose uptake promoting role in skeletal muscle. Of the 2 catalytic a-AMPK isoforms, a2 AMPK is clearly
required for stimulation of glucose transport into muscle by certain stimuli. In contrast, no clear function has yet been
determined for a1 AMPK in skeletal muscle, possibly due to a-AMPK isoform signaling redundancy. By applying low-
intensity twitch-contraction and H2O2 stimulation to activate a1 AMPK, but not
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