有哪些信誉好的足球投注网站alcohol facilitates cd1d loading, subsequent activation of nkt cells, and reduces the incidence of diabetes in nod mice酒精促进cd1d加载,随后激活nkt细胞,可降低糖尿病的发病率在点头老鼠.pdfVIP
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alcohol facilitates cd1d loading, subsequent activation of nkt cells, and reduces the incidence of diabetes in nod mice酒精促进cd1d加载,随后激活nkt细胞,可降低糖尿病的发病率在点头老鼠
Alcohol Facilitates CD1d Loading, Subsequent Activation
of NKT Cells, and Reduces the Incidence of Diabetes in
NOD Mice
1 2 2 3
Karsten Buschard *, Axel Kornerup Hansen , Karen Jensen , Dicky J. Lindenbergh-Kortleve , Lilian F. de
3 2 2 4 2 1
Ruiter , Thomas C. Krohn , Majbritt R. Hufeldt , Finn K. Vogensen , Bent Aasted , Thomas Osterbye ,
5 6 7
Bart O. Roep , Colin de Haar , Edward E. Nieuwenhuis
1 Bartholin Instituttet, Rigshospitalet, Copenhagen, Denmark, 2 Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen,
Frederiksberg, Denmark, 3 Laboratory of Pediatrics and Department of Pediatric Gastroenterology, Erasmus MC, Rotterdam, The Netherlands, 4 Department of Food
Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark, 5 Department of Immunohaematology and Blood Transfusion, Leiden University
Medical Center, Leiden, The Netherlands, 6 Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands, 7 Department of Paediatric
Gastroenterology, Wilhelmina Children’s Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
Abstract
Background: Ethanol (‘alcohol’) is a partly hydrophobic detergent that may affect the accessibility of glycolipids thereby
influencing immunological effects of these molecules.
Methods: The study included cellular in vitro tests using a-galactosylceramide (aGalCer), and in vivo NOD mice experiments
detecting diabetes incidence and performing behavioural and bacterial analyses.
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