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alcoholism and alternative splicing of candidate genes酗酒和候选基因的选择性剪接
Int. J. Environ. Res. Public Health 2010, 7, 1448-1466; doi:10.3390/ijerph7041448
OPEN ACCESS
International Journal of
Environmental Research and
Public Health
ISSN 1660-4601
/journal/ijerph
Review
Alcoholism and Alternative Splicing of Candidate Genes
Toshikazu Sasabe and Shoichi Ishiura *
Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1,
Komaba, Meguro-ku, Tokyo, 153-8902, Japan; E-Mail: cc087707@mail.ecc.u-tokyo.ac.jp
* Author to whom correspondence should be addressed; E-Mail: cishiura@mail.ecc.u-tokyo.ac.jp;
Tel.: +81-3-5454-6739; Fax: +81-3-5454-6739.
Received: 26 February 2010; in revised form: 21 March 2010 / Accepted: 23 March 2010 /
Published: 30 March 2010
Abstract: Gene expression studies have shown that expression patterns of several genes
have changed during the development of alcoholism. Gene expression is regulated not only
at the level of transcription but also through alternative splicing of pre-mRNA. In this
review, we discuss some of the evidence suggesting that alternative splicing of candidate
genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the
mechanisms underlying the pathophysiology of alcoholism. These reports suggest that
ab
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