有哪些信誉好的足球投注网站age-related disease association of endogenous γ-h2ax foci in mononuclear cells derived from leukapheresis与年龄相关的疾病协会的内生在单核细胞来源于leukapheresisγ-h2ax疫源地.pdfVIP
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age-related disease association of endogenous γ-h2ax foci in mononuclear cells derived from leukapheresis与年龄相关的疾病协会的内生在单核细胞来源于leukapheresisγ-h2ax疫源地
Age-Related Disease Association of Endogenous c-H2AX
Foci in Mononuclear Cells Derived from Leukapheresis
1 1 1¤ 2 3
Shepherd H. Schurman , Christopher A. Dunn , Rebecca Greaves , Binbing Yu , Luigi Ferrucci ,
1 1 1
Deborah L. Croteau , Michael M. Seidman , Vilhelm A. Bohr *
1 Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America, 2 Laboratory of
Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America, 3 Clinical Research
Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Abstract
The phosphorylated form of histone H2AX (c-H2AX) forms immunohistochemically detectable foci at DNA double strand
breaks. In peripheral blood mononuclear cells (PBMCs) derived from leukapheresis from patients enrolled in the Baltimore
Longitudinal Study of Aging, c-H2AX foci increased in a linear fashion with regards to age, peaking at ,57 years. The
relationship between the frequency of c-H2AX foci and age-related pathologies was assessed. We found a statistically
significant (p = 0.023) 50% increase in foci in PBMCs derived from patients with a known history of vitamin D deficiency. In
addition, there were trends toward increased c-H2AX foci in patients with cataracts (34% increase, p ,0.10) and in sleep
apnea patients (44%, p ,0.10). Among patients $57 y/o, we found a significant (p = 0.037) 36% increase in the number of c-
H2AX foci/cell for patients with
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