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advances in carcinogenic metal toxicity and potential molecular markers进步致癌金属毒性和潜在的分子标记
Int. J. Mol. Sci. 2011, 12, 9576-9595; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
Advances in Carcinogenic Metal Toxicity and Potential
Molecular Markers
Preeyaporn Koedrith 1,2 and Young Rok Seo 1,2,*
1 Department of Life Science, Dongguk University, 30 Pildong-ro 1-gil (26 Pildong 3-ga), Jung-gu,
Seoul 100-715, Korea; E-Mail: pkoedrith@
2 Institute of Environmental Medicine for Green Chemistry, Dongguk University, 30 Pildong-ro 1-gil
(26 Pildong 3-ga), Jung-gu, Seoul 100-715, Korea
* Author to whom correspondence should be addressed; E-Mail: seoyr@;
Tel.: +82-2-2260-3321; Fax: +82-2-2760-0674.
Received: 13 September 2011; in revised form: 28 October 2011 / Accepted: 12 December 2011 /
Published: 20 December 2011
Abstract: Metal compounds such as arsenic, cadmium, chromium, cobalt, lead, mercury,
and nickel are classified as carcinogens affecting human health through occupational
and environmental exposure. However, the underlying mechanisms involved in tumor
formation are not well clarified. Interference of metal homeostasis may result in oxidative
stress which represents an imbalance between production of free radicals and the system’s
ability to readily detoxify reactive intermediates. This event consequently causes DNA
damage, lipid peroxidation, protein modification, and possibly symptomatic
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