adenosine deaminase polymorphism affects sleep eeg spectral power in a large epidemiological sample腺苷脱氨酶多态性影响睡眠脑电图频谱功率在一个大样本的流行病学.pdfVIP
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adenosine deaminase polymorphism affects sleep eeg spectral power in a large epidemiological sample腺苷脱氨酶多态性影响睡眠脑电图频谱功率在一个大样本的流行病学
Adenosine Deaminase Polymorphism Affects Sleep EEG
Spectral Power in a Large Epidemiological Sample
1 1,2 1 ˜ 3
Diego Robles Mazzotti , Camila Guindalini *, Altay Alves Lino de Souza , Joao Ricardo Sato ,
´ 1 1 1
Rogerio Santos-Silva , Lia Rita Azeredo Bittencourt , Sergio Tufik
˜ ˜ ´ ˆ ´
1 Departamento de Psicobiologia – Universidade Federal de Sao Paulo - Sao Paulo, Brazil, 2 Laboratorio de Neurociencias Clınicas (LiNC) – Departamento de Psiquiatria -
˜ ˜ ´ ˜ ˜ ´
Universidade Federal de Sao Paulo - Sao Paulo, Brazil, 3 Centro de Matematica, Computac¸ao e Cognic¸ao – Universidade Federal do ABC – Santo Andre, Brazil
Abstract
Slow wave oscillations in the electroencephalogram (EEG) during sleep may reflect both sleep need and intensity, which are
implied in homeostatic regulation. Adenosine is strongly implicated in sleep homeostasis, and a single nucleotide
polymorphism in the adenosine deaminase gene (ADA G22A) has been associated with deeper and more efficient sleep. The
present study verified the association between the ADA G22A polymorphism and changes in sleep EEG spectral power (from
˜
C3-A2, C4-A1, O1-A2, and O2-A1 derivations) in the Epidemiologic Sleep
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