有哪些信誉好的足球投注网站aberrant gabaa receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice在cortico-thalamic网络异常对gabaa受体介导抑制琥珀semialdehyde脱氢酶缺乏的老鼠.pdfVIP
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aberrant gabaa receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice在cortico-thalamic网络异常对gabaa受体介导抑制琥珀semialdehyde脱氢酶缺乏的老鼠
Aberrant GABAA Receptor-Mediated Inhibition in
Cortico-Thalamic Networks of Succinic Semialdehyde
Dehydrogenase Deficient Mice
1 2 1 1
Adam C. Errington *, K. Michael Gibson , Vincenzo Crunelli , David W. Cope
1 School of Biosciences, Cardiff University, Cardiff, United Kingdom, 2 Department of Biological Sciences, Michigan Technological University, Houghton, Michigan, United
States of America
Abstract
Aberrant c-aminobutyric acid type A (GABA ) receptor-mediated inhibition in cortico-thalamic networks remains an
A
attractive mechanism for typical absence seizure genesis. Using the whole-cell patch clamp technique we examined ‘phasic’
and ‘tonic’ GABAA inhibition in thalamocortical neurons of somatosensory (ventrobasal, VB) thalamus, nucleus reticularis
thalami (NRT) neurons, and layer 5/6 pyramidal neurons of the somatosensory (barrel) cortex of succinic semialdehyde
dehydrogenase (SSADH) knock-out (SSADH2/ 2) mice that replicate human SSADH deficiency and exhibit typical absence
seizures. We found increased sIPSC frequency in both VB and NRT neurons and larger sIPSC amplitude in VB neurons of
SSADH2/ 2 mice compared to wild-type animals, demonstrating an increase in total phasic inhibition in thalamus of
SSADH2/ 2 mice. mIPSCs in both VB and NRT neurons were no different between genotypes, although there remained a
trend toward more events in SSADH2/ 2 mice. In cortical layer 5/6 pyramidal neurons, sIPSCs were fewer but larger in
SSADH2/ 2 mice, a feature retained by mIPSCs. Tonic currents were larger in both thalamocortical neurons and layer 5/6
pyramidal neurons from SSADH2/
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