a yeast model of fustls-dependent cytotoxicity的酵母模型fustls-dependent细胞毒性.pdfVIP

A Yeast Model of FUS/TLS-Dependent Cytotoxicity 1,2 3,4 3,4 1 5,6 7 Shulin Ju , Daniel F. Tardiff , Haesun Han , Kanneganti Divya , Quan Zhong , Lynne E. Maquat , 8 8 8 3,4 1,2 Daryl A. Bosco , Lawrence J. Hayward , Robert H. Brown Jr. , Susan Lindquist , Dagmar Ringe *, Gregory A. Petsko1,2* 1 Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America, 2 Department of Neurology and Center for Neurologic Diseases, Harvard Medical School and Brigham Women’s Hospital, Cambridge, Massachusetts, United States of America, 3 Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, 4 Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 5 Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, 6 Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, 7 Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, United States of America, 8 Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America Abstract FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial