有哪些信誉好的足球投注网站a genetic and pathologic study of a denv2 clinical isolate capable of inducing encephalitis and hematological disturbances in immunocompetent micedenv2临床分离的基因和病理研究能够诱导脑炎和血液在小鼠免疫活性的干扰.pdfVIP
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a genetic and pathologic study of a denv2 clinical isolate capable of inducing encephalitis and hematological disturbances in immunocompetent micedenv2临床分离的基因和病理研究能够诱导脑炎和血液在小鼠免疫活性的干扰
A Genetic and Pathologic Study of a DENV2 Clinical
Isolate Capable of Inducing Encephalitis and
Hematological Disturbances in Immunocompetent Mice
1 ´ 1 ´ 1,2
Jaime Henrique Amorim , Raıza Sales Pereira Bizerra , Rubens Prince dos Santos Alves , Maria
3 ´ 4 5 ´
Elisabete Sbrogio-Almeida , Jose Eduardo Levi , Margareth Lara Capurro , Luıs Carlos de Souza
Ferreira1*
˜ ´ ˜
1Vaccine Development Laboratory, Department of Microbiology, University of Sao Paulo, Brazil, 2 State University of Santa Cruz, Ilheus, Brazil, 3 Butantan Institute, Sao
˜ ˜
Paulo, Brazil, 4 Institute of Tropical Medicine, University of Sao Paulo, Brazil, 5 Department of Parasitology, University of Sao Paulo, Brazil
Abstract
Dengue virus (DENV) is the causative agent of dengue fever (DF), a mosquito-borne illness endemic to tropical and
subtropical regions. There is currently no effective drug or vaccine formulation for the prevention of DF and its more severe
forms, i.e., dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). There are two generally available
experimental models for the study of DENV pathogenicity as well as the evaluation of potential vaccine candidates. The first
model consists of non-human primates, which do not develop symptoms but rather a transient viremia. Second, mouse-
adapte
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