有哪些信誉好的足球投注网站a genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci全基因组研究复制链接3 p22-24极端人类长寿和识别可能的额外的位点.pdfVIP
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a genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci全基因组研究复制链接3 p22-24极端人类长寿和识别可能的额外的位点
A Genome-Wide Study Replicates Linkage of 3p22-24 to
Extreme Longevity in Humans and Identifies Possible
Additional Loci
1,2 ¤ 2¤ 1,2 2,4 3
Richard A. Kerber * , Elizabeth O’Brien , Kenneth M. Boucher , Ken R. Smith , Richard M. Cawthon
1 Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America, 2 Huntsman Cancer Institute, University of Utah, Salt Lake City,
Utah, United States of America, 3 Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America, 4 Department of Family and
Consumer Studies, Salt Lake City, Utah, United States of America
Abstract
Background: Although there is abundant evidence that human longevity is heritable, efforts to map loci responsible for
variation in human lifespan have had limited success.
Methodology/Principal Findings: We identified individuals from a large multigenerational population database (the Utah
Population Database) who exhibited high levels of both familial longevity and individual longevity. This selection identified
325 related ‘‘affected individuals’’, defined as those in the top quartile for both excess longevity (EL = observed lifespan –
expected lifespan) and familial excess longevity (FEL = weighted average EL across all relatives). A whole-genome scan for
genetic linkage was performed on this sample using a panel of 1100 microsatellite markers. A strongly suggestive peak
(Z = 4.2, Monte Carlo-adjusted p-value 0.09) was observed in the vicinity of D3S3547 on chromosome 3p24.1, at a point
nearly identical to that reported recently by an independent team of researchers from Harvard Medical School (HMS) [1].
Meta-analysis of linkage scores on 3p
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