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3-chloro-4-fluoro-n-{[3-(4-methoxyphenyl)-1-phenyl-1h-pyrazol- 4-yl]methyl}aniline3-chloro-4-fluoro-n - {[3 -(4-methoxyphenyl)1-phenyl-1h-pyrazol 4-yl]甲基}苯胺
Molbank 2009, M640
OPEN ACCESS
molbank
ISSN 1422-8599
/journal/molbank
Short Note
3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-
pyrazol-4-yl]methyl}aniline
Sandhya Bawa, Fasih Ahmad and Suresh Kumar *
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard
University), New Delhi-110062, India
* Author to whom correspondence should be addressed; E-Mail: sureshkr.2006@.
Received: 12 October 2009 / Accepted: 29 October 2009 / Published: 5 November 2009
Abstract: A direct reductive amination of 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-
carbaldehyde 2 with 3-chloro-4-flouroaniline using NaBH /I as a reducing agent is
4 2
described. The reaction was carried out in MeOH under neutral conditions at room
temperature to give the secondary amine, 3-chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-
phenyl-1H-pyrazol-4-yl]methyl}aniline (3).
Keywords: reductive amination; pyrazolylamine; NaBH4/I2
1. Introduction
The direct reductive amination of aldehydes and ketones with a metal hydride reagent is one of the
most useful methods for the synthesis of secondary and tertiary amines [1–4]. Secondary amines and
their derivatives constitute many biologically active molecules and are important intermediates in the
synthesis of active pharmaceutical ingredients, dyes, and fine chemicals [5–7]. In continuation of our
interest in the synthesis
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