a genetic association study of single nucleotide polymorphisms in fgfr1op2wit3.0 and long-term atrophy of edentulous mandible单核苷酸多态性的遗传关联研究fgfr1op2wit3.0和长期无齿的下颌骨萎缩.pdfVIP

A Genetic Association Study of Single Nucleotide Polymorphisms in FGFR1OP2/wit3.0 and Long-Term Atrophy of Edentulous Mandible 1,2,3 1,4 1 5 5 6 Jaijam Suwanwela , Jaehoon Lee , Audrey Lin , T. Cemal Ucer , Hugh Devlin , Janet Sinsheimer , Neal R. Garrett1, Ichiro Nishimura1,2* 1The Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, University of California Los Angeles (UCLA) School of Dentistry, Los Angeles, California, United States of America, 2 Division of Oral Biology and Medicine, University of California Los Angeles (UCLA) School of Dentistry, Los Angeles, California, United States of America, 3 Department of Prosthodontics, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand, 4 Department of Prosthodontics, College of Dentistry, Yonsei University, Seoul, Korea, 5 School of Dentistry, University of Manchester, Manchester, United Kingdom, 6 Departments of Human Genetics and Biomathematics, David Geffen School of Medicine at the University of California Los Angeles (UCLA), Los Angeles, California, United States of America Abstract Background: After dental extraction, the external surface of alveolar bone undergoes resorption at various rates, and a group of patients develop excessive jawbone atrophy. Oral mucosa overlying the atrophied jawbone is unusually thin; therefore, we have hypothesized that excessive jawbone atrophy may be associated with abnormal oral mucosa contraction. FGFR1OP2/wit3.0, a cytoskeleton molecule initially identified in oral wound fibroblasts, has been shown to induce oral mucosa contraction a