有哪些信誉好的足球投注网站2,3-dihydro-1h-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors—synthesis, radiolabeling and biodistribution2,3-dihydro-1h-cyclopenta[b]喹啉衍生物作为乙酰胆碱酯酶inhibitors-synthesis,放射性标记和biodistribution.pdfVIP
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2,3-dihydro-1h-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors—synthesis, radiolabeling and biodistribution2,3-dihydro-1h-cyclopenta[b]喹啉衍生物作为乙酰胆碱酯酶inhibitors-synthesis,放射性标记和biodistribution
Int. J. Mol. Sci. 2012, 13, 10067-10090; doi:10.3390/ijms130810067
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
2,3-Dihydro-1H-cyclopenta[b]quinoline Derivatives as
Acetylcholinesterase Inhibitors—Synthesis, Radiolabeling
and Biodistribution
Paweł Szymański 1,*, Alice Lázničková 2, Milan Lázniček 2, Marek Bajda 3, Barbara Malawska 3,
1 1
Magdalena Markowicz and Elżbieta Mikiciuk-Olasik
1 Department of Pharmaceutical Chemistry and Drug Analyses, Medical University,
ul. Muszyńskiego 1, Lodz 90-151, Poland; E-Mails: magdalena.markowicz@umed.lodz.pl (M.M.);
elzbieta.mikiciuk-olasik@umed.lodz.pl (E.M.-O.)
2 Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203,
Hradec Kralove CZ-50005, Czech Republic; E-Mails: alice.laznickova@faf.cuni.cz (A.L.);
milan.laznicek@faf.cuni.cz (M.L.)
3 Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University
Medical College, Medyczna 9, Krakow 30-688, Poland; E-Mails: marek.bajda@.pl (M.B.);
barbara.malawska@.pl (B.M.)
* Author to whom correspondence should be addressed; E-Mail: pawel.szymanski@umed.lodz.pl;
Tel./Fax: +48-42-677-9250.
Received: 14 June 2012; in revised form: 7 July 2012 / Accepted: 6 August 2012 /
Published: 13 August 2012
Abstract: In the present study we describe the synthesis and biological assessment of new
tacrine analogs in the course of inhibitio
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