有哪些信誉好的足球投注网站a genetic screen for attenuated growth identifies genes crucial for intraerythrocytic development of plasmodium falciparum遗传筛查减毒增长识别基因intraerythrocytic恶性疟原虫的发展的关键.pdfVIP
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a genetic screen for attenuated growth identifies genes crucial for intraerythrocytic development of plasmodium falciparum遗传筛查减毒增长识别基因intraerythrocytic恶性疟原虫的发展的关键
A Genetic Screen for Attenuated Growth Identifies
Genes Crucial for Intraerythrocytic Development of
Plasmodium falciparum
. .
Bharath Balu , Naresh Singh , Steven P. Maher, John H. Adams*
Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, United States of America
Abstract
A majority of the Plasmodium falciparum genome codes for genes with unknown functions, which presents a major
challenge to understanding the parasite’s biology. Large-scale functional analysis of the parasite genome is essential to
pave the way for novel therapeutic intervention strategies against the disease and yet difficulties in genetic manipulation of
this deadly human malaria parasite have been a major hindrance for functional analysis of its genome. Here, we used a
forward functional genomic approach to study P. falciparum and identify genes important for optimal parasite development
in the disease-causing, intraerythrocytic stages. We analyzed 123 piggyBac insertion mutants of P. falciparum for
proliferation efficiency in the intraerythrocytic stages, in vitro. Almost 50% of the analyzed mutants showed significant
reduction in proliferation efficiency, with 20% displaying severe defects. Functional categorization of genes in the severely
attenuated mutants revealed significant enrichment for RNA binding proteins, suggesting the significance of post-
transcriptional gene regulation in parasite development and emphasizing its importance as an antimalarial target. This
study demonstrates the feasibility of much needed forward genetics approaches for P. falciparum to better characterize its
genome and accelerate drug and vaccine development.
Citation: Balu B, Sin
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