有哪些信誉好的足球投注网站a comparison of approaches to estimate the inbreeding coefficient and pairwise relatedness using genomic and pedigree data in a sheep population比较的方法来估计近交系数和成对亲缘使用基因组和纯种羊人口中的数据.pdfVIP
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a comparison of approaches to estimate the inbreeding coefficient and pairwise relatedness using genomic and pedigree data in a sheep population比较的方法来估计近交系数和成对亲缘使用基因组和纯种羊人口中的数据
A Comparison of Approaches to Estimate the Inbreeding
Coefficient and Pairwise Relatedness Using Genomic and
Pedigree Data in a Sheep Population
1,2 ´ 1 1 ´ 1 1
Meng-Hua Li , Ismo Stranden , Timo Tiirikka , Marja-Liisa Sevon-Aimonen , Juha Kantanen *
1 Biotechnology and Food Research, MTT Agrifood Research Finland, Jokioinen, Finland, 2 Key Laboratory of Animal Ecology and Conservation Biology, Institute of
Zoology, Chinese Academy of Sciences, Beijing, China
Abstract
Genome-wide SNP data provide a powerful tool to estimate pairwise relatedness among individuals and individual
inbreeding coefficient. The aim of this study was to compare methods for estimating the two parameters in a Finnsheep
population based on genome-wide SNPs and genealogies, separately. This study included ninety-nine Finnsheep in Finland
that differed in coat colours (white, black, brown, grey, and black/white spotted) and were from a large pedigree comprising
319 119 animals. All the individuals were genotyped with the Illumina Ovine SNP50K BeadChip by the International Sheep
Genomics Consortium. We identified three genetic subpopulations that corresponded approximately with the coat colours
(grey, white, and black and brown) of the sheep. We detected a significant subdivision among the colour types (FST = 5.4%,
P,0.05). We applied robust algorithms for the genomic estimation of individual inbreeding (FSNP) and pairwise relatedness
(WSNP) as implemented in the programs KING and PLINK, respectively. Estimates of the two parameters from pedigrees (FPED
and WPED) were computed using the RelaX2 program. Values of the two parameters estimated from genomic
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