a comparison of three methods to measure asthma in epidemiologic studies results from the danish national birth cohort比较三种方法测量哮喘的流行病学研究结果从丹麦国家出生队列.pdfVIP

A Comparison of Three Methods to Measure Asthma in Epidemiologic Studies: Results from the Danish National Birth Cohort 1 1 2,3 4 ¨ 1 Susanne Hansen *, Marin Strøm , Ekaterina Maslova , Erik Lykke Mortensen , Charlotta Granstrom , Sjurdur F. Olsen1,3 1 Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, 2 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, 3 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, 4 Institute of Public Health and Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark Abstract Asthma is a heterogeneous outcome and how the condition should be measured to best capture clinically relevant disease in epidemiologic studies remains unclear. We compared three methods of measuring asthma in the Danish National Birth Cohort (n.50.000). When the children were 7 years old, the prevalence of asthma was estimated from a self-administered questionnaire using parental report of doctor diagnoses, ICD-10 diagnoses from a population-based hospitalization registry, and data on anti-asthmatic medication from a population-based prescription registry. We assessed the agreement between the methods using kappa statistics. Highest prevalence of asthma was found using the prescription registry (32.2%) followed by the self-report (12.0%) and the hospitalization registry (6.6%). We found a substantial non-overlap between the methods (kappa = 0.21–0.38). When all three methods were combined the asthma prevalence was 3.6%. In conclusion, self- reported asthma, ICD-10 diagnoses from a hospitaliza