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a bistable model of cell polarity细胞极性的双稳态模型
A Bistable Model of Cell Polarity
1 2 3 4 5,6,7
Matteo Semplice , Andrea Veglio , Giovanni Naldi *, Guido Serini , Andrea Gamba
`
1 Department of Physics and Mathematics, Universita dell’Insubria, Como, Italy, 2 Genomes and Genetics Department, Unit Physics of Biological Systems, Institut Pasteur,
`
Paris, France, 3 Department of Mathematics ‘‘F. Enriques’’, Universita degli studi di Milano, Milano, Italy, 4 Laboratory of Cell Adhesion Dynamics, Institute for Cancer
`
Research and Treatment and Department of Oncological Sciences, School of Medicine, Universita degli studi di Torino, Candiolo, Italy, 5 Department of Mathematics,
Politecnico di Torino, Torino, Italy, 6 Laboratory of Systems Biology, Institute for Cancer Research and Treatment, Candiolo, Italy, 7 INFN, Torino, Italy
Abstract
Ultrasensitivity, as described by Goldbeter and Koshland, has been considered for a long time as a way to realize bistable
switches in biological systems. It is not as well recognized that when ultrasensitivity and reinforcing feedback loops are present
in a spatially distributed system such as the cell plasmamembrane, they may induce bistability and spatial separation of the
system into distinct signaling phases. Here we suggest that bistability of ultrasensitive signaling pathways in a diffusive
environment provides a basic mechanism to realize cell membrane polarity. Cell membrane polarization is a fundamental
process implicated in several basic biological phenomena, such as differentiation, proliferation, migration and morphogenesis
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