a bi-functional anti-thrombosis protein containing both direct-acting fibrin(ogen)olytic and plasminogen-activating activitiesbi-functional抗血栓蛋白包含直接的纤维蛋白(ogen)olytic和plasminogen-activating活动.pdfVIP

A Bi-Functional Anti-Thrombosis Protein Containing Both Direct-Acting Fibrin(ogen)olytic and Plasminogen- Activating Activities 1,6. 1,6. 1,6. 1,6 1,6 1,6 5 Hailong Yang , Yipeng Wang , Yao Xiao , Ying Wang , Jing Wu , Cunbao Liu , Huahu Ye , 4 3 1,2 Fengliang Li , Haining Yu *, Ren Lai * 1 Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China, 2 Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu, China, 3 School of Life Science and Biotechnology, Dalian University of Technology, Dalian, Liaoning, China, 4 Department of Laboratory Medicine, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China, 5 Institute of Biotechnology, The Academy of Military Medical Sciences, Beijing, China, 6 Graduate School of the Chinese Academy of Sciences, Beijing, China Abstract Direct-acting fibrin(ogen)olytic agents such as plasmin have been proved to contain effective and safety thrombolytic potential. Unfortunately, plasmin is ineffective when administered by the intravenous route because it was neutralized by plasma antiplasmin. Direct-acting fibrin(ogen)olytic agents with resistance against antiplasmin will brighten the prospect of anti-thrombosis. As reported in ‘Compendium of Materia Medica’, the insect of Eupolyphaga sinensis Walker has been used as traditional anti-thrombosis medicine without bleeding risk for several hundreds years. Currently, we have identified a fibrin(ogen)olytic protein (Eupolytin1) containing both fibrin(ogen)olytic and plasminogen-activating (PA) activities from th