4-methylenesterols from a sponge theonella swinhoei从海绵4-methylenesterols theonella swinhoei.pdfVIP

Mar. Drugs 2012, 10, 1536-1544; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article 4-Methylenesterols from a Sponge Theonella swinhoei Jheng-Kun Guo 1,2, Ching-Ying Chiang 3, Mei-Chin Lu 1,4, Wen-Been Chang 1,2,* and Jui-Hsin Su 1,4,5,* 1 National Museum of Marine Biology Aquarium, Pingtung 944, Taiwan; E-Mails: idun031177@ (J.-K.G.); jinx6609@.tw (M.-C.L.) 2 Graduate Institute of Marine Biodiversity and Evolutionary Biology, National Dong Hwa University, Pingtung 944, Taiwan 3 Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan; E-Mail: cyjang@.tw 4 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 5 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan * Authors to whom correspondence should be addressed; E-Mails: wenbeen@.tw (W.-B.C.); x2219@.tw (J.-H.S.); Tel.: +886-8-8825001 (ext. 3126); Fax: +886-8-8825087. Received: 11 June 2012; in revised form: 28 June 2012 / Accepted: 11 July 2012 / Published: 19 July 2012 Abstract: Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited signi