有哪些信誉好的足球投注网站2-decenoic acid ethyl ester, a compound that elicits neurotrophin-like intracellular signals, facilitating functional recovery from cerebral infarction in mice2-decenoic酸乙酯化合物,抒发neurotrophin-like胞内信号,促进功能恢复在老鼠脑梗塞.pdfVIP
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2-decenoic acid ethyl ester, a compound that elicits neurotrophin-like intracellular signals, facilitating functional recovery from cerebral infarction in mice2-decenoic酸乙酯化合物,抒发neurotrophin-like胞内信号,促进功能恢复在老鼠脑梗塞
Int. J. Mol. Sci. 2012, 13, 4968-4981; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
2-Decenoic Acid Ethyl Ester, a Compound That Elicits
Neurotrophin-like Intracellular Signals, Facilitating Functional
Recovery from Cerebral Infarction in Mice
Yoshitaka Tanaka 1,2, Hidefumi Fukumitsu 1, Hitomi Soumiya 1, Shinichi Yoshimura 2,
Toru Iwama 2 and Shoei Furukawa 1,*
1 Laboratory of Molecular Biology, Gifu Pharmaceutical University, Daigaku-nishi, 1-25-4,
Gifu 501-1190, Japan; E-Mails: tanakay@gifu-u.ac.jp (Y.T.); hfukumi@gifu-pu.ac.jp (H.F.):
somiya@gifu-pu.ac.jp (H.S.)
2 Department of Neurosurgery, Gifu University Graduate School of Medicine, Yanagido 1-1,
Gifu 501-1194, Japan; E-Mails: s-yoshi@gifu-u.ac.jp (S.Y.); tiwama@gifu-u.ac.jp (T.I.)
* Author to whom correspondence should be addressed; E-Mail: furukawa@gifu-pu.ac.jp;
Tel.: +81-58-230-8100; Fax: +81-58-230-8105.
Received: 12 March 2012; in revised form: 6 April 2012 / Accepted: 11 April 2012 /
Published: 19 April 2012
Abstract: In our previous study, we found that trans-2-decenoic acid ethyl ester (DAEE), a
derivative of a medium-chain fatty acid, elicits neurotrophin-like signals including the
activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in cultured mouse
cortical neurons. Here, we examined the efficacy of intraperitoneal administration of
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