阿米福汀滴注速度与恶心呕吐的相关性分析.PDFVIP

阿米福汀滴注速度与恶心呕吐的相关性分析 缪永杰 a b ，王君芬 (舟山市人民医院，a.药剂科，b.护理部，浙江 舟山 316000) 摘要：目的 研究阿米福汀滴注速度的快慢与恶心呕吐分级和骨髓保护作用的相关性。方法 采用随机的分组方法将 35 例化疗患者分为 A 组 17 例和 B 组 18 例，均接受相同周期的化疗。2 组 I 周期(对照组) ，化疗前用阿米福汀时间严格控制 在 15 min 内；II 周期( 实验组) ，化疗前用阿米福汀时间控制在 60 min 内。2 个周期后评价恶心呕吐分级和血液毒性。结 果 A 组和 B 组患者在 I 周期(对照组) 出现恶心呕吐的人次、程度均明显高于 II 周期( 实验组)(P0.01) ；而 A 组和 B 组患 者在 I 周期和 II 周期化疗后的外周血毒性无显著性差异 (P0.05) 。结论 阿米福汀滴注速度的快慢，对骨髓保护作用无 明显差异，但适当延长阿米福汀使用时间，可以明显减少恶心呕吐的发生率。 关键词：阿米福汀；滴注速度；恶心呕吐；骨髓保护 中图分类号：R969.3 文献标志码：B 文章编号：1007-7693(2010)06-0557-03 Amifostine Infusion Rate and the Correlation of Malignant Vomiting MIAO Yongjie, WANG Junfen(Zhoushan Hospital, a. Department of Pharmaceutics; b. Department of Nursing, Zhoushan 316000, China) ABSTRACT: OBJECTIVE To study the correlation between the drip rate of amifostine and the degree of nausea, the protection of bone marrow. METHODS There were 35 patients who were divided into group A and group B randomly, all of them received two periods of chemotherapies. In period I (control period), the patients were administrated with amifostine in 15 minutes before chemotherapeutics, however, the time was regulated in 60 minutes in prerion II(experimental period). The degree of nausea and toxicity of bone marrow were estimated after two periods. RESULTS Incidence rate of nausea in period I highly exceeded than period II for patients both in group A and B (P0.01), but there was no obvious difference of the toxicity of bone marrow for patients between group A and B in period I and II. CONCLUSION There is no evidence showed that drip rate of amifostine was correlated to protection of bone marrow, whatever, to prolong the time of amifostine is thought to reduce the incidence rate of nausea. KEY WORDS: amifostine; drip rate; nausea; protection of bone marrow 阿米福汀是一种广谱选择性细胞保护剂，它选 1 临床资料 择性保护正