有哪些信誉好的足球投注网站Care of high-dose methotrexate for adults with acute lymphoblastic leukemia（照顾大剂量甲氨蝶呤为成人急性淋巴细胞白血病）.doc
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Care of high-dose methotrexate for adults with acute lymphoblastic leukemia（照顾大剂量甲氨蝶呤为成人急性淋巴细胞白血病）
Care of high-dose methotrexate for adults with acute lymphoblastic leukemia
Large doses of methotrexate (HD-MTX), is the prevention and treatment of adult acute lymphoblastic leukemia, and extramedullary leukemia and systemic consolidation and effective measures to strengthen the treatment. Tetrahydrofolate (CF4 calcium rescue, but the HD-MTX is a metabolic anti-tumor drug toxicity, the course of treatment is often accompanied by varying degrees of toxicity, to ensure the successful completion of chemotherapy, nursing is the key. our department from October 2008 to December 2010, 20 cases of adult acute lymphoblastic leukemia patients, HD- MTX intensive therapy and have achieved good results, are as follows:
1 clinical data 1.1 General Information 13 males and 7 females, age 16-48 years old, median age was 28 years old, were diagnosed with acute lymphoblastic leukemia. Had used standard VMLP (vincristine, Mi Tuoen quinone, L-asparaginase enzyme prednisone program or VDLP (vincristine, daunorubicin, L-asparaginase, prednisone program 1-2 courses, achieved complete remission.
1.2 treatment and the effect of This course of treatment before the patients were routinely check the heart, liver function, blood and normal oral and perianal skin and mucous membrane integrity of MTX each dose 3-5g/m2 first 1/3 of total surprise the amount added to the saline 100ml The 0.5h drop finished, the margin by adding 1000ml saline 23.5h uniform drops finished, the infusion should be dark. Open a path to add a lot of liquids (2000-3000ml / day) to maintain 72h, adequate hydration and alkalization. More water to ensure that the daily urine output is less than 2000ml. Gargle daily with leucovorin 24mg added to the saline 500ml configured as a mouthwash, gargle. the end of the HD-MTX intravenously 12 hours began to be rescued by CF4, and its total is 10-15% of the total of MTX, the first 1/2 the amount of normal saline 0.5h drops in 100ml finished, after each interval of
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