第六节 淋巴瘤（Sixth section lymphoma）.docVIP

第六节 淋巴瘤（Sixth section lymphoma） Sixth section lymphoma (Lymphoma) Lymphoma is a malignant tumor that occurs primarily in lymph nodes or lymph nodes. Clinical painless, progressive lymph node enlargement as the main manifestation. Etiology and pathogenesis The cause of human lymphoma is unclear. In animals, there are a variety of viruses that can cause lymphomas, such as Rous sarcoma viruses that cause lymphoma in poultry. But in humans, only two viruses are clearly related to lymphoma, namely, EB virus and human T cell lymphoma / leukemia virus (HTLV - 1). The EB virus has been found to have close relationship with the etiology of African children in Burkitt lymphoma, EB virus DNA was extracted from the Burkitt fraction in the nuclei of lymph. But lymphomas of the same type outside Africa were not associated with the EB virus. 1980 isolated a unique retrovirus from tumor cell lines in patients with cutaneous T cell lymphoma (C RNA virus) named as human T cell lymphoma / leukemia virus, and adult T cell leukemia virus found in Japan in 1976 (ATLV) is the same virus. All these indicate that viruses play an important role in the etiology of human lymphoma. These phenomena show that the possible mechanism of the lymphoma in hereditary or acquired immune disorder, lymphocyte long-term by exogenous or endogenous antigen stimulation, leading to proliferation, inhibition of T due to the absence or dysfunction of cells, lymphocytes lose feedback control normal proliferative response to antigen stimulation, resulting in unlimited proliferation finally, associated with lymphoma. Pathology and classification The typical pathological features are: lymphoma of lymph node and normal follicular structure for a large number of abnormal lymphocyte cells or tissue damage, membrane and surrounding tissue was also invaded and the abnormal cells; mitotic index increased. Lymphoma is a heterogeneous group of diseases that is divided into Hodgkins disease (HD) and non Huo Jinqis lymphoma (