第17章 治疗中枢神经系统退行性疾病药（The seventeenth chapter treats the central nervous system degenerative disease medicine）.docVIP

第17章 治疗中枢神经系统退行性疾病药（The seventeenth chapter treats the central nervous system degenerative disease medicine） The seventeenth chapter treats the central nervous system degenerative disease medicine Basic Requirements Key and difficult points Teaching hours Synopsis 1 basic requirements [TOP] 1.1 to master the pharmacological action of levodopa and its mechanism, clinical application and adverse reactions. 1.2 familiar with Cabi do Ba, selegiline, nitrate for pharmacological action and clinical application of entacapone, bromocriptine, amantadine; the classification of drugs for Alzheimers disease and medicine. 1.3 understand and trihexyphenidyl Benzatropine application. 2 key and difficult [TOP] 2.1 key Pharmacological action and application of representative drugs 2.2 difficulties Represents the mechanism of action of drugs 3 teaching hours [TOP] Recommendation 1 hours 4 Summary [TOP] Drugs for the treatment of degenerative diseases of the central nervous system (I) anti Parkinson disease drugs; Parkinsons disease (Parkinson s disease, PD) is one of the main performance for the central nervous system degenerative disease of extrapyramidal dysfunction, typical symptoms of resting tremor, muscle rigidity and bradykinesia) and ataxia, usually accompanied by mental decline. 1. pathogenesis of Parkinsons disease PD is associated with a significant decrease in dopamine (DA) levels in striatum. At present, the accepted theory is dopamine theory and oxidative stress theory. The former pointed out that the decrease of DA synthesis decreased DA content in striatum of nigrostriatal dopaminergic and cholinergic nerve function imbalance, cholinergic neuron activity is relatively high, the extrapyramidal hyperfunction, occurrence of paralysis agitans. The latter explains why dopaminergic neuronal degeneration, namely in oxidative stress, resulting in a large number of patients with PD DA H2O2 and superoxide anion oxidation process, Fe2+ in the substantia nigra of catalyst, furt