第19章 镇痛药（The nineteenth chapter is analgesic）.docVIP

第19章 镇痛药（The nineteenth chapter is analgesic） The nineteenth chapter is analgesic Basic Requirements Key and difficult points Teaching hours Synopsis 1 basic requirements [TOP] 1.1 master of morphine, pethidine injection, he pharmacological action, mechanism of action, clinical application of dezocine and adverse reaction. 1.2 familiar with the classification of clinical analgesics and the dangers of abuse of analgesics. 1.3 understand that opioid receptors and endogenous morphine like substances in the process and its significance; effect of opioid receptor and the receptor agonist of opioid analgesics; basic chemical structure and structure-activity relationship; opioid receptor antagonist naloxone and naltrexone. 2 key and difficult [TOP] 2.1 key Pharmacological action and application of representative drugs. 2.2 difficulties The mechanism of opioid analgesics. 3 teaching hours [TOP] Recommendation 2 hours. 4 Summary [TOP] Analgesic (1) concepts and characteristics of pain and analgesics: 1. pain is a painful sensation caused by tissue damage or potential tissue damage, often accompanied by unpleasant emotions, even cardiovascular and respiratory changes. It is a protective mechanism of the organism, which reminds the body to avoid or deal with injuries. It is also a common symptom of many diseases in the clinic. They are divided into somatic pain, visceral pain, and neuropathic pain. 2. a drug that produces analgesia by relieving opioid receptors in a specific part of the central nervous system and relieving pain caused by unpleasant pain. Because of its analgesic effects associated with opioid receptor agonists, and easy to produce drug dependence or addiction, easily lead to drug abuse and drug withdrawal symptoms, so called opioid analgesics or narcotic analgesics and narcotic analgesics. (two) opioid receptor agonists Morphine (morphine) [pharmacological effects] CNS system: (1) analgesia sedation: effective for a variety of pain (for the role of blunt pai