第11章肾上腺素受体阻断药（The eleventh chapter adrenergic receptor blocking drugs）.docVIP

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第11章肾上腺素受体阻断药（The eleventh chapter adrenergic receptor blocking drugs）.doc

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第11章肾上腺素受体阻断药（The eleventh chapter adrenergic receptor blocking drugs）

第11章肾上腺素受体阻断药（The eleventh chapter adrenergic receptor blocking drugs） The eleventh chapter adrenergic receptor blocking drugs Basic Requirements Key and difficult points Teaching hours Synopsis 1 basic requirements [TOP] 1.1 to master the classification, pharmacological effects, clinical application and adverse reactions of adrenergic receptor blockers. 1.2 be familiar with the mechanism and process of adrenergic receptor blocking drugs. 2 key and difficult [TOP] 2.1 key Pharmacological action and clinical application of adrenergic receptor blocking drugs. 3 teaching hours [TOP] Recommendation 4 hours 4 abstracts [TOP], Section 1, verse second, verse third 4.1 section 1 alpha adrenergic receptor blocker [TOP] Alpha receptor blockers can selectively bind with alpha adrenergic receptor, which in itself is not excited or less excited adrenergic receptor can interfere with noradrenergic neurotransmitter and adrenergic receptor agonists combined with alpha receptor, resulting in adrenolytic. They can turn the pressor effect of epinephrine into a hypotensive effect, a phenomenon known as adrenaline reversal. For norepinephrine, which mainly acts on the vascular alpha receptor, they only cancel or attenuate their pressor effect without reversal. There was no effect on the hypotensive effect of isoproterenol, which mainly acts on beta receptors. Alpha receptor blocking drugs have a wide range of pharmacological effects. According to the selectivity of these drugs to alpha 1 and alpha 2 receptors, they can be divided into three groups: 1. nonselective alpha receptor blocker Short acting class: phentolamine, and Phentolamine Long acting class: phenol benzyl 2. selective alpha 1 receptor blocker, prazosin (prazosin). 3. selective alpha 2 receptor blocker Henbin (yohimbine) Selective non alpha blocking agents Phentolamine and cefazolin Phentolamine (phentolamine) and tolazoline [pharmacological action] phentolamine and tolazoline can competitively block the receptor alpha,