Slurry hydrogenation in a continuous flow （在连续流浆加氢）.pdfVIP

s i BERTRAND BUISSON s e STEVE DONEGAN h DENIS WRAY t ANA PARRACHO n y JAYNE GAMBLE Guermeur s PHILIPPE CAZE Celine JEREMY JORDA m CELINE GUERMEUR o t s u Slurry hydrogenation C - e in a continuous flow reactor v i t c for pharmaceutical application e p s r e p ABSTRACT question is how to benefit from enhanced mass and heat y transfer for industrial production up to several hundred tons r Multiphase hydrogenation using heterogeneous catalyst was per year which requires production rates at least 100 times t conducted in a glass continuous flow reactor from Corning higher. The pressure drop induced by a packed-bed usually s at the Centre for Process Innovation. The effect of temperature, prevents increasing the flow rates: Pressures of 8 and 80 u hydrogen molar ratio, residence time, catalyst content and bars have been reported for a liquid flow rate of only 1 d concentration were studied using noble-metal slurry catalyst. ml/min (9-11). The wash coating techniques are catalyst n Efficient heat and mass transfer allow achieving full conversion specific and would require important technical development I with residence time lower than 1 minute and reduced catal