Diagnostic accuracy of bone metastases （骨转移的诊断准确性）.pdf

ORIGINAL ARTICLE Annals of Nuclear Medicine Vol. 20, No. 6, 399–408, 2006 Diagnostic accuracy of bone metastases detection in cancer patients: Comparison between bone scintigraphy and whole-body FDG-PET Ryota FUJIMOTO, Tatsuya HIGASHI, Yuji NAKAMOTO, Tadashi HARA, Andrej LYSHCHIK, Koichi ISHIZU, Hidekazu KAWASHIMA, Shigeto KAWASE, Toru FUJITA, Tsuneo SAGA and Kaori TOGASHI Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has become widely available and an important oncological technique. To evaluate the influence of PET on detection of bone metastasis, we compared the diagnostic accuracy of PET and conventional bone scintigraphy (BS) in a variety of cancer patients. Methods: Consecutive ninety-five patients with various cancers, who received both PET and BS within one month, were retrospectively analyzed. A whole-body PET (from face to upper thigh) and a standard whole body BS were performed and these images were interpreted by two experienced nuclear medicine physicians with and without patient information using monitor diagnosis. Each image interpretation was performed according to 8 separate areas (skull, vertebra, upper limbs, sternum and clavicles, scapula, ribs, pelvis, and lower limbs) using a 5-point-scale (0: definitely negative, 1: probably negative, 2: equivocal, 3: probably positive, 4: definitely positive for bone metastasis). Results: Twenty-one of 95 patients (22.1%) with 43 of 760 areas (5.7%) of bone metastases were finally confirmed. In untreated patients,