identification and characterization of a dual-acting antinematodal agent against the pinewood nematode, bursaphelenchus xylophilus识别和描述的双作用antinematodal代理对松木线虫,bursaphelenchus xylophilus.pdfVIP

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identification and characterization of a dual-acting antinematodal agent against the pinewood nematode, bursaphelenchus xylophilus识别和描述的双作用antinematodal代理对松木线虫,bursaphelenchus xylophilus.pdf

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identification and characterization of a dual-acting antinematodal agent against the pinewood nematode, bursaphelenchus xylophilus识别和描述的双作用antinematodal代理对松木线虫,bursaphelenchus xylophilus

Identification and Characterization of a Dual-Acting Antinematodal Agent against the Pinewood Nematode, Bursaphelenchus xylophilus 1 1 1 1 2 2 Wan-Suk Oh , Pan-Young Jeong , Hyoe-Jin Joo , Jeong-Eui Lee , Yil-Seong Moon , Hyang-Mi Cheon , 3 4 4 1 Jung-Ho Kim , Yong-Uk Lee , Yhong-Hee Shim , Young-Ki Paik * 1 Yonsei Proteome Research Center and Department of Biochemistry, College of Life Sciences and Biotechnology, WCU Program, Yonsei University, Seoul, Korea, 2 South Forest Research Center, Jinju, Gyeongsangnam-do, Korea, 3 Hanwha Chemical Research and Development Center, Taejon, Korea, 4 Department of Bioscience and Biotechnology, and Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea Abstract The pinewood nematode (PWN), Bursaphelenchus xylophilus, is a mycophagous and phytophagous pathogen responsible for the current widespread epidemic of the pine wilt disease, which has become a major threat to pine forests throughout the world. Despite the availability of several preventive trunk-injection agents, no therapeutic trunk-injection agent for eradication of PWN currently exists. In the characterization of basic physiological properties of B. xylophilus YB-1 isolates, we established a high-throughput screening (HTS) method that identifies potential hits within approximately 7 h. Using this HTS method, we screened 206 compounds with known activities, mostly antifungal, for antinematodal activities and identified HWY-4213 (1-n-undecyl-2-[2-fluorphenyl] methyl-3,4-dihydro-6,7-dimethoxy-isoquinolinium chloride), a highly water-soluble protoberberine derivative, as