high seroprevalence of rift valley fever and evidence for endemic circulation in mbeya region, tanzania, in a cross-sectional study裂谷热的高seroprevalence和证据在mbeya地区特有的循环,坦桑尼亚,横断面研究.pdfVIP
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high seroprevalence of rift valley fever and evidence for endemic circulation in mbeya region, tanzania, in a cross-sectional study裂谷热的高seroprevalence和证据在mbeya地区特有的循环,坦桑尼亚,横断面研究
High Seroprevalence of Rift Valley Fever and Evidence for Endemic Circulation in Mbeya Region, Tanzania, in a Cross-Sectional Study 1,2 . 1,2. 1,2 1,2,3 1,2,3 Norbert Heinrich * , Elmar Saathoff , Nina Weller , Petra Clowes , Inge Kroidl , 3 4 3 ¨ 1,2 5 Elias Ntinginya , Harun Machibya , Leonard Maboko , Thomas Loscher , Gerhard Dobler , Michael Hoelscher1,2,3 1 Division of Infectious Diseases, Medical Center of the University of Munich, Munich, Germany, 2 German Centre for Infection Research (DZIF), University of Munich, Munich, Germany, 3 NIMR-Mbeya Medical Research Programme, Mbeya, Tanzania, 4 Mbeya Regional Medical Office, Ministry of Health, Mbeya, Tanzania, 5 Bundeswehr Institute of Microbiology, Munich, Germany Abstract Background: The Rift Valley fever virus (RVFV) is an arthropod-borne phlebovirus. RVFV mostly causes outbreaks among domestic ruminants with a major economic impact. Human infections are associated with these events, with a fatality rate of 0.5–2%. Since the virus is able to use many mosquito species of temperate climates as vectors, it has a high potential to spread to outside Africa. Methodology/Principal Findings: We conducted a stratified, cross-sectional sero-prevalence survey in 1228 participants from Mbeya region, southwestern Tanzania. Samples were selected from 17,872 persons who took part in a cohort study in 2007 and 2008. RVFV IgG status was determined by indirect immunofluorescence. Possible risk factors were analyzed using uni- and multi-variable Poisson regression models. We found a unique local maximu
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