growth environment and sex differences in lipids, body shape and diabetes risk生长环境和性别差异在脂质,体型和糖尿病的风险.pdfVIP

Growth Environment and Sex Differences in Lipids, Body Shape and Diabetes Risk 1 1 1 1 1 2,3 1 C. Mary Schooling *, Tai Hing Lam , G. Neil Thomas , Benjamin J. Cowling , Michelle Heys , Edward D. Janus , Gabriel M. Leung , for the Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee 1 Department of Community Medicine and School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong SAR, China, 2 Clinical Biochemistry Unit, The University of Hong Kong, Pokfulam, Hong Kong SAR, China, 3 Department of Medicine, Western Hospital, Footscray, Victoria, Australia Background. Sex differences in lipids and body shape, but not diabetes, increase at puberty. Hong Kong Chinese are mainly first or second generation migrants from China, who have shared an economically developed environment for years, but grew up in very different environments in Hong Kong or contemporaneously undeveloped Guangdong, China. We assessed if environment during growth had sex-specific associations with lipids and body shape, but not diabetes. Methodology and Principal Findings. We used multivariable regression in a population-based cross-sectional study, undertaken from 1994 to 1996, of 2537 Hong Kong Chinese residents aged 25 to 74 years with clinical measurements of ischaemic heart disease (IHD) risk, including HDL-cholesterol, ApoB, diabetes and obesity. Waist-hip ratio was higher (mean difference 0.01, 95% CI 0.001 to 0.02) in men, who had grown up in an economically developed rather than undeveloped environment, as was apolipoprotein B (0.05 g/L, 95% CI 0.001 to 0.10), adjusted for age, socio-economic status and lifestyle. In contrast, the same comparison was associated in women with lower waist-hip ratio ( 20.01, 95% CI 20.001 to 20.02) and hig