有哪些信誉好的足球投注网站halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathwayhalofuginone anti-proliferative影响急性早幼粒细胞白血病的调制转化生长因子β信号通路.pdfVIP
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halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathwayhalofuginone anti-proliferative影响急性早幼粒细胞白血病的调制转化生长因子β信号通路
Halofuginone Has Anti-Proliferative Effects in Acute Promyelocytic Leukemia by Modulating the Transforming Growth Factor Beta Signaling Pathway 1. 1. ´ 1 ´ 2 Lorena L. de Figueiredo-Pontes , Patricia A. Assis , Barbara A. A. Santana-Lemos , Rafael H. Jacomo , ´ 1 1 ´ 1 ´ ´ 1 1 Ana Sılvia G. Lima , Aglair B. Garcia , Carolina H. Thome , Amelia G. Araujo , Rodrigo A. Panepucci , 1 3 ˜ 1 1 Marco A. Zago , Arnon Nagler , Roberto P. Falcao , Eduardo M. Rego * ˜ ˜ ˜ ˜ 1 Hematology Division of the Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, 2 Hematology ´ ´ Division of the Department of Internal Medicine, Medical School of the University of Brasılia, Brasılia, Brazil, 3 Hematology Division and Cord Blood Bank, Chaim Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel Abstract Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARa) expression in acute promyelocytic leukemia (APL) impairs transforming growth factor beta (TGF b) signaling, leading to cell growth advantage. Halofuginone (HF), a
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