genetic variants in er cofactor genes and endometrial cancer risker辅因子基因的遗传变异和子宫内膜癌的风险.pdfVIP

Genetic Variants in ER Cofactor Genes and Endometrial Cancer Risk 1 1 1 2 ´ 3 2 Yuqing Li , Hui-Qi Low , Jia Nee Foo , Hatef Darabi , Kristjana Einarsdottir , Keith Humphreys , 4 A NEC S Group 4,5 6,7 6 7 Amanda Spurdle , , Douglas F. Easton , Deborah J. Thompson , Alison M. Dunning , 7 2 8 2 1 Paul D. P. Pharoah , Kamila Czene , Kee Seng Chia , Per Hall , Jianjun Liu * 1 Human Genetics, Genome Institute of Singapore, Singapore, Singapore, 2 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 3 Telethon Institute for Child Health Research, University of Western Australia, Western Australia, Australia, 4 Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia, 5 The Australian National Endometrial Cancer Study (ANECS) Group, Queensland Institute of Medical Research, Brisbane, Queensland, Australia, 6 Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, 7 Department of Oncology, University of Cambridge, Cambridge, United Kingdom, 8 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore Abstract Given that the transcriptional regulatory activity of estrogen receptor (ER) is modulated by its biochemical cofactors, genetic variation within the ER cofactor genes may alter cellular response to estrogen exposure and consequently modify the risk for endo