有哪些信誉好的足球投注网站genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men基因变异染色体2 q35,5 p12,6 q25.1 10 q26.13,16 q12.1影响男性的患乳腺癌的风险.pdfVIP
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genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men基因变异染色体2 q35,5 p12,6 q25.1 10 q26.13,16 q12.1影响男性的患乳腺癌的风险
Genetic Variants at Chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 Influence the Risk of Breast Cancer in Men 1. 2. 2 1 3 1 Nick Orr *, Rosie Cooke , Michael Jones , Olivia Fletcher , Frank Dudbridge , Sarah Chilcott-Burns , 1 4 4 1 2 Katarzyna Tomczyk , Peter Broderick , Richard Houlston , Alan Ashworth , Anthony Swerdlow 1The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom, 2 Section of Epidemiology, The Institute of Cancer Research, Sutton, United Kingdom, 3 Department of Non-Communicable Disease Epidemiology, The London School of Hygiene and Tropical Medicine, London, United Kingdom, 4 Section of Cancer Genetics, The Institute of Cancer Research, Sutton, United Kingdom Abstract Male breast cancer accounts for approximately 1% of all breast cancer. To date, risk factors for male breast cancer are poorly defined, but certain risk factors and genetic features appear common to both male and female breast cancer. Genome-wide association studies (GWAS) have recently identified common single nucleotide polymorphisms (SNPs) that influence female breast cancer risk; 12 of these have been independently replicated. To examine if these variants contribute to male breast cancer risk, we genotyped 433 male breast cancer cases and 1,569 controls. Five SNPs showed a statistically significant association with male breast cancer: r (2q35) (odds ratio (OR) = 1.30, p = 7.98 61024), r (5p12) (OR = 1.26, p = 0.007), rs9383938 (6q25.1) (OR = 1.39, p = 0.00
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