generation and characterization of conditional heparin-binding egf-like growth factor knockout mice生成和特征条件heparin-binding egf-like生长因子基因敲除小鼠.pdfVIP

Generation and Characterization of Conditional Heparin- Binding EGF-Like Growth Factor Knockout Mice 1 1 1 1 2 Atsushi Oyagi , Yasuhisa Oida , Kenichi Kakefuda , Masamitsu Shimazawa , Norifumi Shioda , Shigeki 2 3 4 5 6 Moriguchi , Kiyoyuki Kitaichi , Daisuke Nanba , Kazumasa Yamaguchi , Yasuhide Furuta , Kohji 2 4 1 Fukunaga , Shigeki Higashiyama , Hideaki Hara * 1 Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan, 2 Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan, 3 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, Japan, 4 Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan, 5 Nihon Bioresearch Center Inc., Gifu, Japan, 6 Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America Abstract Recently, neurotrophic factors and cytokines have been shown to be associated in psychiatric disorders, such as schizophrenia, bipolar disorder, and depression. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family, serves as a neurotrophic molecular and plays a significant role in the brain. We generated mice in which HB-EGF activity is disrupted specifically in the ventral forebrain. These knockout mice showed (a) b