gabaergic and cortical and subcortical glutamatergic axon terminals contain cb1 cannabinoid receptors in the ventromedial nucleus of the hypothalamusgaba ergic和皮层和皮层下glutamatergic轴突末端含有cb1大麻素受体在下丘脑腹内侧核.pdfVIP

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gabaergic and cortical and subcortical glutamatergic axon terminals contain cb1 cannabinoid receptors in the ventromedial nucleus of the hypothalamusgaba ergic和皮层和皮层下glutamatergic轴突末端含有cb1大麻素受体在下丘脑腹内侧核.pdf

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gabaergic and cortical and subcortical glutamatergic axon terminals contain cb1 cannabinoid receptors in the ventromedial nucleus of the hypothalamusgaba ergic和皮层和皮层下glutamatergic轴突末端含有cb1大麻素受体在下丘脑腹内侧核

GABAergic and Cortical and Subcortical Glutamatergic Axon Terminals Contain CB1 Cannabinoid Receptors in the Ventromedial Nucleus of the Hypothalamus 1 1 1 1 Leire Reguero , Nagore Puente , Izaskun Elezgarai , Juan Mendizabal-Zubiaga , Miren Josune 1 1 1 ´ 2 ´ 2 Canduela , Ianire Buceta , Almudena Ramos , Juan Suarez , Fernando Rodrıguez de Fonseca , Giovanni Marsicano3, Pedro Grandes 1* ´ ´ 1 Department of Neurosciences, Faculty of Medicine and Dentistry, Basque Country University, Leioa, Spain, 2 Fundacion IMABIS, Malaga, Spain, 3 ‘‘Endocannabinoids and ´ Neuroadaptation’’, INSERM U862 NeuroCentre Magendie, Universite Bordeaux 2, Bordeaux, France Abstract Background: Type-1 cannabinoid receptors (CB R) are enriched in the hypothalamus, particularly in the ventromedial 1 hypothalamic nucleus (VMH) that participates in homeostatic and behavioral functions including food intake. Although CB R activation modulates excitatory and inhibitory synaptic transmission in the brain, CB R contribution to the molecular 1 1 architecture of the excitatory and inhibitory synaptic terminals in the VMH is not known. Therefore, the aim of this study was to investigate the precise subc