有哪些信誉好的足球投注网站five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls meta-analysis of 130 studies五个谷胱甘肽s-transferase基因变异在23452例肺癌和23452年控制130个研究的荟萃分析.pdfVIP
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five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls meta-analysis of 130 studies五个谷胱甘肽s-transferase基因变异在23452例肺癌和23452年控制130个研究的荟萃分析
PLoS MEDICINE Five Glutathione S-Transferase Gene Variants in 23,452 Cases of Lung Cancer and 30,397 Controls: Meta-Analysis of 130 Studies 1* 2 3 1,2 1 Zheng Ye , Honglin Song , Julian P. T. Higgins , Paul Pharoah , John Danesh 1 Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Cambridge, United Kingdom, 2 Department of Oncology, University of Cambridge, Strangeways Site, Cambridge, United Kingdom, 3 Public Health Genetics Unit and MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom Funding: JD has been supported by A B S T R A C T the Raymond and Beverly Sackler Award in the Medical Sciences. The funders had no role in study design, Background data collection and analysis, decision to publish, or preparation of the Glutathione S-transferases (GSTs) are known to abolish or reduce the activities of intracellular manuscript. enzymes that help detoxify environmental carcinogens, such as those found in tobacco smoke. It has been suggested that polymorphisms in the GST genes are risk factors for lung cancer, but Competing Interests: The authors have declared that no competing a large number of studies have reported apparently conflicting results. interests exist. Academic Editor: Cathryn Lewis, Methods and Findings Guy’s King’s and St Thomas’ School of Medicine, United Kingdom Literature-based meta-analysis was supplemented by tabular data from investigators of all relevant studies of five GST polymorphisms (GSTM1
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