gain and loss of multiple genes during the evolution of helicobacter pylori得失的多个基因在幽门螺杆菌的进化.pdfVIP

Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori 1 1 2 3 4 5 Helga Gressmann , Bodo Linz , Rohit Ghai , Klaus-Peter Pleissner , Ralph Schlapbach , Yoshio Yamaoka , 6 6 1 1* Christian Kraft , Sebastian Suerbaum , Thomas F. Meyer , Mark Achtman ¨ ¨ ¨ 1 Department of Molecular Biology, Max-Planck-Institut fur Infektionsbiologie, Berlin, Germany, 2 Institut fur Medizinische Mikrobiologie, Justus-Liebig-Universitat, Giessen, ¨ Germany, 3 Core Facility Bioinformatics, Max-Planck-Institut fur Infektionsbiologie, Berlin, Germany, 4 Functional Genomics Center Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland, 5 Department of Medicine, M.E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, United States of America, ¨ 6 Medizinische Hochschule Hannover, Institut fur Medizinische Mikrobiologie und Krankenhaushygiene, Hannover, Germany Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but it was not clear whether these populations also differ in gene content. To address this question, we tested 56 globally representative strains of H. pylori and four strains of Helicobacter acinonychis with whole genome microarrays. Of the weighted average of 1,531 genes present in the two sequenced genomes, 25% are absent in at least one strai