functional polymorphisms in il13 are protective against high schistosoma mansoni infection intensity in a brazilian population功能多态性在使用il13曼氏裂体吸虫感染预防高强度在巴西的人口.pdfVIP

Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population 1,2 3 4 3 2 Audrey V. Grant *, Maria Ilma Araujo , Eduardo Vieira Ponte , Ricardo Riccio Oliveira , Peisong Gao , Alvaro A. Cruz3,4, Kathleen C. Barnes1,2, Terri H. Beaty1 1 Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, United States of America, 2 Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of America, 3 Servic¸o de Imunologia, Hospital ´ ´ Universitario Professor Edgard Santos, Salvador, Bahia, Brazil, 4 Programa para o Controle da Asma e Rinite Alergica na Bahia, Federal University of Bahia School of Medicine, Salvador, Bahia, Brazil Abstract Background: IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure. Methodology/Principal Findings: Two functional polymorphisms in IL13, rs1800925 (or c.1-1111C.T) and rs20541 (or R130Q) were previously found to be associated with Schistosoma hematobium infection intensity. They have not been thoroughly explored in S. mansoni-endemic populations, however, and were selected along with 5 tagging SNPs for genotyping in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area of Conde, Bahia