有哪些信誉好的足球投注网站functional profiling reveals critical role for mirna in differentiation of human mesenchymal stem cells功能分析揭示了关键作用microrna在人类间充质干细胞的分化.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
functional profiling reveals critical role for mirna in differentiation of human mesenchymal stem cells功能分析揭示了关键作用microrna在人类间充质干细胞的分化
Functional Profiling Reveals Critical Role for miRNA in Differentiation of Human Mesenchymal Stem Cells 1 1 1 1 1 Angela Schoolmeesters , Teresa Eklund , Devin Leake , Annaleen Vermeulen , Queta Smith , 2 1 Shelley Force Aldred , Yuriy Fedorov * 1Thermo Fisher Scientific, Lafayette, Colorado, United States of America, 2 SwitchGear Genomics, Menlo Park, California, United States of America Abstract Background: Mesenchymal stem (MS) cells are excellent candidates for cell-based therapeutic strategies to regenerate injured tissue. Although human MS cells can be isolated from bone marrow and directed to differentiate by means of an osteogenic pathway, the regulation of cell-fate determination is not well understood. Recent reports identify critical roles for microRNAs (miRNAs), regulators of gene expression either by inhibiting the translation or by stimulating the degradation of target mRNAs. Methodology/Principal Findings: In this study, we employed a library of miRNA inhibitors to evaluate the role of miRNAs in early osteogenic differentiation of human MS cells. We discovered that miR-148b, -27a and -489 are essential for the regulation of osteogenesis: miR-27a and miR-489 down-regulate while miR-148b up-regulates differentiation. Modulation of these miRNAs induced osteogenesis in the absence of other external differentiation cues and restored osteogenic potential in high passage number human MS cells. Conclusions/Significance: Overall, we have demonstrated the utility of the functional profiling strategy for unraveling complex miRNA pathways. Our findings indicate that miRNAs regulate early osteogenic differentiation in human MS cells:
您可能关注的文档
- first international external quality assessment study on molecular and serological methods for yellow fever diagnosis第一个国际外部质量评估研究分子和血清学方法对黄热病诊断.pdf
- first isolation and direct evidence for the existence of large small-mammal reservoirs of leptospira sp. in madagascar首先隔离和小型哺乳动物存在的直接证据座大型水库的钩端螺旋体sp.马达加斯加.pdf
- first molecular epidemiological study of cutaneous leishmaniasis in libya在利比亚第一皮肤利什曼病的分子流行病学研究.pdf
- first known feeding trace of the eocene bottom-dwelling fish notogoneus osculus and its paleontological significance始新世的最早喂养跟踪深海鱼类notogoneus osculus及其古生物学意义.pdf
- first report of 13 species of culicoides (diptera ceratopogonidae) in mainland portugal and azores by morphological and molecular characterization第一份报告的13种库蠓属(双翅目ceratopogonidae)在葡萄牙和大陆亚速尔群岛的形态和分子鉴定.pdf
- first qualification study of serum biomarkers as indicators of total body burden of osteoarthritis第一次资格研究血清生物标志物指标的全身骨关节炎的负担.pdf
- first report of sylvatic denv-2-associated dengue hemorrhagic fever in west africa第一次报告的森林型denv-2-associated登革出血热在西非.pdf
- first reported case of cryptococcus gattii in the southeastern usa implications for travel-associated acquisition of an emerging pathogen首次报道例隐球菌在美国东南部gattii影响旅途收购一个新兴的病原体.pdf
- first things first effectiveness and scalability of a basic prehospital trauma care program for lay first-responders in kampala, uganda首先基本院前创伤护理程序的有效性和可伸缩性在坎帕拉躺在第一时间作出回应,乌干达.pdf
- first report of colonies of sylvatic triatoma infestans (hemiptera reduviidae) in the paraguayan chaco, using a trained dog第一次报告的殖民地森林型triatoma 5(半翅类reduviidae)在巴拉圭查科,使用经过训练的狗.pdf
- functional maps of protein complexes from quantitative genetic interaction data功能蛋白复合物的地图从定量基因交互数据.pdf
- functional pstirsai polymorphism in cyp2e1 is associated with the development, progression and poor outcome of gastric cancer功能在cyp2e1 pstirsai多态性与开发、发展和贫困的结果胃癌.pdf
- functional reconstitution into liposomes of purified human rhcg ammonia channel功能调整成脂质体的净化人类rhcg氨通道.pdf
- functional ramifications for the loss of p-selectin expression on hematopoietic and leukemic stem cells造血功能影响的损失p-selectin表情和白血病干细胞.pdf
- functional neuronal cells generated by human parthenogenetic stem cells功能性神经细胞所产生的人类孤雌生殖的干细胞.pdf
- functional relationship between skull form and feeding mechanics in sphenodon, and implications for diapsid skull development头骨的形式功能关系和喂养力学在冈,双窝型头骨发展和影响.pdf
- functional representation of enzymes by specific peptides由特定的肽酶的功能表示.pdf
- functional role of glutamine 28 and arginine 39 in double stranded rna cleavage by human pancreatic ribonuclease功能角色谷氨酰胺28和精氨酸39人类胰核糖核酸酶在双链rna乳沟.pdf
- functional rotation of the transporter acrb insights into drug extrusion from simulations旋转功能的见解药物转运体acrb挤压模拟.pdf
- functional significance of allelic variation at methuselah, an aging gene in drosophila玛士撒拉等位变异的功能意义,老龄化基因在果蝇.pdf
文档评论（0）