functional polymorphism -31cg in the promoter of birc5 gene and risk of nasopharyngeal carcinoma among chinese功能多态性-31 cg birc5基因的启动子和鼻咽癌在中国的风险.pdfVIP

Functional Polymorphism -31C/G in the Promoter of BIRC5 Gene and Risk of Nasopharyngeal Carcinoma among Chinese 1,2. 1. 1 1,2 2 2 Fuchao Ma , Hongxing Zhang , Yun Zhai , Wenfeng Huang , Chang Zhao , Shengqiu Ou , Hong 2 2 1 1,2 1 1 1 1 Zhou , Wenzhao Yuan , Zhifu Wang , Hongxue Wang , Wei Yue , Lixia Yu , Peiyao Li , Xia Xia , Mi 1 1 2 1,3 2 1 Cai , Yang Zhang , Ying Cui , Fuchu He , Yilong Ma *, Gangqiao Zhou * 1 State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China, 2 Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi, China, 3 Institutes of Biomedical Sciences, Fudan University, Shanghai, China Abstract Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5, also called as survivin) is a member of the inhibitor of apoptosis protein (IAP) family, which plays an important role in the occurrence and progression of cancer. Recently, a polymorphism in the promoter of BIRC5, -31C/G (rs9904341), was shown to influence BIRC5 expression. Methods: We examined whether the -31C/G was related to the risk of developing nasopharyngeal carcinoma (NPC) in a case-control population from Guangxi province in southern China, which consists of 855 patients with NPC and 1036 controls. This polymorphism was genotyped by TaqMan assay. The genetic as