有哪些信誉好的足球投注网站five years of antimalarial resistance marker surveillance in gaza province, mozambique, following artemisinin-based combination therapy roll out五年的抗疟抗性标记监测在加沙,莫桑比克,推出以青蒿素为基础的联合治疗.pdfVIP
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five years of antimalarial resistance marker surveillance in gaza province, mozambique, following artemisinin-based combination therapy roll out五年的抗疟抗性标记监测在加沙,莫桑比克,推出以青蒿素为基础的联合治疗
Five Years of Antimalarial Resistance Marker Surveillance in Gaza Province, Mozambique, Following Artemisinin- Based Combination Therapy Roll Out 1 2,3 4 5 1 2 Jaishree Raman *, Katya Mauff , Pedro Muianga , Abdul Mussa , Rajendra Maharaj , Karen I. Barnes 1 Malaria Research Programme, Medical Research Council, Durban, South Africa, 2 Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa, 3 Department of Statistical Science, University of Cape Town, Cape Town, South Africa, 4 Gaza Province Directorate of Health, Xai Xai, Mozambique, 5 National Malaria Control Programme, Maputo City, Mozambique Abstract Antimalarial drug resistance is a major obstacle to malaria control and eventual elimination. The routine surveillance for molecular marker of resistance is an efficient way to assess drug efficacy, which remains feasible in areas where malaria control interventions have succeeded in substantially reducing malaria transmission. Community based asexual parasite prevalence surveys were conducted annually in sentinel sites in Gaza Province, Mozambique from 2006 until 2010, before, during and after antimalarial policy changes to artesunate plus sulfadoxine-pyrimethamine in 2006 and to artemether- lumefantrine in 2008. Genetic analysis of dhfr, dhps, crt, and mdr1 resistant genes was conducted on 3 331 (14.4%) Plasmodium falciparum PCR positive samples collected over the study period from 23 229 children aged 2 to 15 years. The quintuple dhfr/dhps mutation associated with sulfadoxine-pyrimethamine resistance increased from 56.2% at baseline to 75.8% by 2010. At baseline the crt76T and mdr186Y mutant
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