有哪些信誉好的足球投注网站a salmonella typhimurium-typhi genomic chimera a model to study vi polysaccharide capsule function in vivovi typhimurium-typhi沙门氏菌基因嵌合体模型来研究多糖胶囊函数体内.pdfVIP
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a salmonella typhimurium-typhi genomic chimera a model to study vi polysaccharide capsule function in vivovi typhimurium-typhi沙门氏菌基因嵌合体模型来研究多糖胶囊函数体内
A Salmonella Typhimurium-Typhi Genomic Chimera: A Model to Study Vi Polysaccharide Capsule Function In Vivo 1. 1. 1 1 1 Angela M. Jansen , Lindsay J. Hall , Simon Clare , David Goulding , Kathryn E. Holt , Andrew J. 2 2 1 1 Grant , Piero Mastroeni , Gordon Dougan , Robert A. Kingsley * 1The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, 2 Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom Abstract The Vi capsular polysaccharide is a virulence-associated factor expressed by Salmonella enterica serotype Typhi but absent from virtually all other Salmonella serotypes. In order to study this determinant in vivo, we characterised a Vi-positive S. Typhimurium (C5.507 Vi+), harbouring the Salmonella pathogenicity island (SPI)-7, which encodes the Vi locus. S. Typhimurium C5.507 Vi+ colonised and persisted in mice at similar levels compared to the parent strain, S. Typhimurium C5. However, the innate immune response to infection with C5.507 Vi+ and SGB1, an isogenic derivative not expressing Vi, differed markedly. Infection with C5.507 Vi+ resulted in a significant reduction in cellular trafficking of innate immune cells, including PMN and NK cells, compared to SGB1 Vi2 infected animals. C5.507 Vi+ infection stimulated reduced numbers of TNF-a, MIP-2 and perforin producing cells compared to SGB1 Vi 2. The modulating effect associated with Vi was not observed in MyD882/ 2 and was reduced in TLR42/ 2 mice. The presence of t
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