有哪些信誉好的足球投注网站a safety review and meta-analyses of bevacizumab and ranibizumab off-label versus goldstandard安全审查和贝伐单抗和初标示外与goldstandard的荟萃分析.pdfVIP
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a safety review and meta-analyses of bevacizumab and ranibizumab off-label versus goldstandard安全审查和贝伐单抗和初标示外与goldstandard的荟萃分析
A Safety Review and Meta-Analyses of Bevacizumab and Ranibizumab: Off-Label versus Goldstandard 1 2 2 1 3 Christine Schmucker *, Christoph Ehlken , Hansjuergen T. Agostini , Gerd Antes , Gerta Ruecker , Monika Lelgemann4, Yoon K. Loke5 1 German Cochrane Institute, Institute of Medical Biometry and Medical Informatics, Department of Medical Biometry and Statistics, University Medical Centre Freiburg, Freiburg, Germany, 2 University Eye Hospital, University Medical Centre Freiburg, Freiburg, Germany, 3 Institute of Medical Biometry and Medical Informatics, Department of Medical Biometry and Statistics, University Medical Centre Freiburg, Freiburg, Germany, 4 Medical Advisory Service of the German Health Insurance Funds, Essen, Germany, 5 School of Medicine, University of East Anglia, Norwich, United Kingdom Abstract Background: We set out a systemic review to evaluate whether off-label bevacizumab is as safe as licensed ranibizumab, and whether bevacizumab can be justifiably offered to patients as a treatment for age-related macular degeneration with robust evidence of no differential risk. Methods and Findings: Medline, Embase and the Cochrane Library were searched with no limitations of language and year of publication. We included RCTs with a minimum follow-up of one year which investigated bevacizumab or ranibizumab in direct comparison or against any other control group (indirect comparison). Direct comparison (3 trials, 1333 patients): The one year data show a significantly higher rate of ocular adverse effects (AE) with bevacizumab compared to ranibizumab (RR = 2.8; 95% CI 1.2–6.5). The proportion of patients with serious infections and gastrointestinal disorders was also higher with bevacizumab than with ranibizu
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