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a role for atf2 in regulating mitf and melanoma developmentatf2的作用在调节mitf和黑色素瘤的发展
A Role for ATF2 in Regulating MITF and Melanoma Development 1. 1. 1 1 2 Meera Shah , Anindita Bhoumik , Vikas Goel , Antimone Dewing , Wolfgang Breitwieser , Harriet 3 1 1 1 1 4 Kluger , Stan Krajewski , Maryla Krajewska , Jason DeHart , Eric Lau , David M. Kallenberg , 5 1 4 5 6 Hyeongnam Jeong , Alexey Eroshkin , Dorothy C. Bennett , Lynda Chin , Marcus Bosenberg , Nic 2 1 Jones , Ze’ev A. Ronai * 1 Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America, 2 Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom, 3 Department of Medicine, Yale University, New Haven, Connecticut, United States of America, 4 Basic Medical Sciences, St. George’s, University of London, London, United Kingdom, 5 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, 6 Department of Pathology Yale University, New Haven, Connecticut, United States of America Abstract The transcription factor ATF2 has been shown to attenuate melanoma susceptibility to apoptosis and to promote its ability to form tumors in xenograft models. To directly assess ATF2’s role in melanoma development, we crossed a mouse melanoma model (NrasQ61K::Ink4a2/ 2) with mice expressing a transcriptionally inactive form of ATF2 in melanocytes. In contrast to 7/21 of the NrasQ61K::Ink4a2/ 2 mice, only 1/21 m
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