a nmda receptor antagonist, mk-801 impairs consolidating extinction of auditory conditioned fear responses in a pavlovian modelnmda受体拮抗剂mk - 801损害巩固灭绝的听觉条件在巴甫洛夫恐惧反应模型.pdfVIP

A NMDA Receptor Antagonist, MK-801 Impairs Consolidating Extinction of Auditory Conditioned Fear Responses in a Pavlovian Model 1,2,3. 2. 4. 1 5 4 Jun-Li Liu , Min Li *, Xiao-Rong Dang , Zheng-Hong Wang , Zhi-Ren Rao , Sheng-Xi Wu , 4 4 Yun-Qing Li , Wen Wang * 1 Department of Teaching and Training, Fourth Military Medical University, Xi’an, People’s Republic of China, 2 Department of Psychology, School of Nurse, Third Military Medical University, Chong Qing, People’s Republic of China, 3 Department of Nursing, Qing Hai Health and Professional Technology College, Xi Ning, People’s Republic of China, 4 Department of Anatomy, Histology and embryology; K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi’an, People’s Republic of China, 5 Institute of Neuroscience, Fourth Military Medical University, Xi’an, People’s Republic of China Abstract Background: In auditory fear conditioning, repeated presentation of the tone in the absence of shock leads to extinction of the acquired fear responses. The glutamate N-methyl-D-aspartate receptor (NMDAR) is thought to be involved in the extinction of the conditioned fear responses, but its detailed role in initiating and consolidating or maintaining the fear extinction memory is unclear. Here we investigated this issue by using a NMDAR antagonist, MK-801. Methods/Main Findings: The effects of immediate (beginning at 10 min after the conditioning) and delayed (beginning at 24 h after conditioning) extinctions were first compared with the finding that delayed extinction caused a better and long- lasting (still significant on the 2